Bendroflumethiazide in Pregnancy and Breastfeeding

Risk Factor: CM*
Class: Diuretics

Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
Questions and Answers

Fetal Risk Summary

Bendroflumethiazide is a thiazide diuretic. Animal reproduction studies during the period of organogenesis have not been conducted with this agent.

In a study reported in 1964, 1,011 women received bendroflumethiazide, 5 mg/day, from the 30th week of gestation until delivery in an attempt to prevent preeclampsia and eclampsia (1). No fetal adverse effects were noted.

See Chlorothiazide for other reports of the clinical use of thiazide diuretics in pregnancy and the potential fetal and newborn toxicity of these agents. In general, diuretics are not recommended in the treatment of pregnancy-induced hypertension because of the maternal hypovolemia characteristic of this disease.

[*Risk Factor D if used in pregnancy-induced hypertension.]

Breast Feeding Summary

Bendroflumethiazide has been used to suppress lactation (2). (See Chlorothiazide.)


  1. Cuadros A, Tatum HJ. The prophylactic and therapeutic use of bendroflumethiazide in pregnancy. Am J Obstet Gynecol 1964;89:8917.
  2. Healy M. Suppressing lactation with oral diuretics. Lancet 1961;1:13534.

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Questions and Answers

can you take bendroflumethiazide whilst taking the contraceptive pill?, i am taking bendroflumethiazide (water tablet) to reduce water retention and hopefully lose weight. On the patient information leaflet it said consult doctor if on contraceptive pill does this mean i cant take it?

Ring Your Doctor and Ask Him About That....

Here's some info that might help..

Can Bendroflumethiazide cause problems?
Along with their useful effects all medicines can cause unwanted side effects. These usually improve as your body adjusts to the new medicine. Speak to your doctor or chemist if any of the following side effects continue or become troublesome.
Light-headedness, stomach pains, sexual problems, gout (pain and stiffness in the joints), dry mouth, muscle cramps, or skin rashes.
This medicine can occasionally cause you to lose too much potassium or sodium from the body, which are essential for good health. Severe sickness and diarrhoea may increase your chances of potassium or sodium loss. If you experience this contact your doctor or pharmacist as soon as possible.

Thiazide diuretics act in the kidney to remove water from the blood into the urine, by causing an increase in the removal of salts such as potassium and sodium from the blood. This removal of salts causes water to be drawn out of the blood and into the kidneys, where it is then excreted in the urine.

Removing water from the blood decreases the volume of fluid circulating through the blood vessels. The drop in fluid volume results in a drop in the pressure of the fluid within the blood vessels, which helps to lower high blood pressure. It also decreases the effort required by the heart to pump blood around the body.

There are many conditions which may lead to an accumulation of fluid in the body (oedema). Bendroflumethiazide is commonly used in conditions such as heart failure, where the pumping mechanism of the heart is less effective. It is used to relieve the symptoms of heart failure, such as fluid retention. It is also used to relieve fluid retention from many other causes.

What is it used for?

Excess fluid retention causing swelling (oedema) due to any cause

High blood pressure (hypertension)

Suppression of milk production (lactation) in women


It is recommended that blood tests are performed regularly to monitor the level of potassium in the blood. If this level is too low, potassium supplements may be required.

If you experience any of the following symptoms while taking this medicine you should inform your doctor promptly, so that the amount of fluids and salts in your body can be checked: thirst, lethargy, confusion, weakness, drowsiness, muscle cramps, scanty production of urine, abnormal heart rhythm, seizures, nausea and vomiting.

As diuretics cause your kidneys to produce more urine, you may prefer to take this medicine in the morning rather than before going to bed, as this will reduce the likelihood of you needing to get up in the night to visit the toilet. Seek further advice from your doctor or pharmacist.

Use with caution in


Elderly people


Kidney disease

Liver disease

Low blood potassium levels (hypokalaemia)

Not to be used in

Allergy to thiazides

Diabetic keto-acidosis

Failure of the kidneys to produce urine (anuria)

High levels of calcium in the blood (hypercalcaemia)

Inadequate production of natural steroid hormones by the adrenal glands (Addison's disease)

Severe kidney disease

Severe liver disease

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

This medicine should not be used in pregnancy. Seek medical advice from your doctor.

Bendroflumethiazide whats the use for this drug?,

Thiazide diuretic for hypertension

Bendroflumethiazide is used to treat hypertension (high blood pressure) and oedema (fluid retention), often caused by heart failure. It removes excess water from the body by increasing how often you urinate (pass water) and also widens the blood vessels which helps to reduce blood pressure.

can i take st johns wort with anenolol, amias, bendroflumethiazide, asprin and lipitor?,

You seem to have high blood pressure and high cholesterol. Best to talk to your GP before taking any other medication.

Can a problem with the dijestive system cause the heart to race and cause high blood pressure.serious answers ?, Can a hiatas hernia or similar ptoblems cause high blood pressure.I have noticed that my heart rate increases fairly after eating.can go as high as 170'87. I am already on bendroflumethiazide,have been for a year.i am 58.

You indicate that your heart rate is 170/87? That's your blood pressure. You didn't give your heart rate.
Here's a question or two;
How large a meal are you eating?
Do you feel pressure or pain when your stomach is full?
Are you having increased heart burn?
If you feel increased pressure/pain after a meal, then that can increase your heart rate as well as your blood pressure.
Have you checked your blood pressure before you eat? Try doing that both before and after you eat to see if there is a measurable difference. That will give you a good indication of how much distress eating causes.
If your blood pressure goes up after eating on a consistent basis, you probably want to see your doctor.

I'm very concerned about my mum she has high blood pressure and weights 5.3.wat can i do to help her?, at the moment she taking Bendroflumethiazide 2/5mg, she takes 1 a day in the just so worried i really want to help her.

She weighs 5.3? I don't understand... that 5.3 what?? Lbs?? In that case I'd be worried too!

is it fair to assume that Hydrochlorothiazide 25mg is 10x more in dosage terms than Bendroflumethiazide 2.5mg?, can a ten fold increase in diuretic use result in raised albumin and BUN levels during testing for kidney function. I am a type 1 diabetic and i know that diabetes can cause increased levels but want to exclude the accide ntal over use of this diuretic as a seperate cause as my protein level has increase from 57mg to 314mg in less than 1 year, during this time i have accidentally been taking 25mg of HTZ rather than 2.5mg Bendroflurerthiazide. Can the protein level be reversed if caused purely by over use of diuretics

I have a friend who might be able to answer that. Please wait.

Is urination in a public place still a criminal offence in UK and what is penalty if convicted?, An elderly gentlemen has come to me for help. He often goes out for a long walk and recently the cause of nature gave him an overpowering need to discharge ballast, his problem being that he is on medication called Bendroflumethiazide, which reduces blood pressure by making person go to toilet frequently. But when he went to the nearest public toilet he found it locked, which they apparently do because of vandalising by local yobs. So getting more and more desperate he eventually did the job by a tree in a local park, ensuring nobody was around but not knowing area was monitored by police CCTV. Soon after completion of his action he was horrified to see a police panda car approaching, but says he escaped and shook them off by disappearing into the woods and back home. But he is now frightened to come out, as he says if he is spotted by police, with his picture on CCTV, he will be arrested and so become a criminal. Do others have any advice to pass on to him about this heinious crime

go to the police and explain the medical complaint he has and see if the police will be lenient it is an offence and you get a 30 pound fixed penalty but with his circumstances he could be excused good luck

can i take prescription drugs and vitamins together?, Thyroxine150mg,Paroxetine 20mg,Valsarten 40mg,Bendroflumethiazide 2.5mg,Propranolo Hydrochloride 80mg,Loratadine 10mg with Vitamin B complex cod liver oil oil primrose

One questions why you are taking Vitamin B, cod liver oil and evening primrose? With the exception of alcoholics generalised B vitamin deficiency is unknown in the UK. Evening primrose has only one proven therapeutic effect, it produces a modest statistical reduction in pre-menstrual cyclic mastalgia in women. Cod liver oil is high in vitamin D and omega 3.

The direct answer is that there are however no significant interactions.

does my water tablet have any effect on diabetes?, the water tablet that i take is called bendroflumethiazide

It would be wrong of me to say for sure, but I have heard that if you take this med you should check with your health provider. If he/she already knew you were diabetic when it was prescribed, then there must not be a problem. But ANY doubt should warrant a return visit or phone call to be sure!