Corticotropin/Cosyntropin in Pregnancy and Breastfeeding

Risk Factor: C
Class: Hormones / Pituitary agents

Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
References
Questions and Answers

Fetal Risk Summary

Studies reporting the use of corticotropin in pregnancy have not demonstrated adverse fetal effects (1,2,3 and 4). However, corticosteroids have been suspected of causing malformations (see Hydrocortisone). Because corticotropin stimulates the release of endogenous corticosteroids, this relationship should be considered when prescribing the drug to women in their reproductive years.

Breast Feeding Summary

No data are available.

References

  1. Johnstone FD, Campbell S. Adrenal response in pregnancy to long-acting tetracosactin. J Obstet Gynaecol Br Commonw 1974;81:3637.
  2. Simmer HH, Tulchinsky D, Gold EM, et al. On the regulation of estrogen production by cortisol and ACTH in human pregnancy at term. Am J Obstet Gynecol 1974;119:28396.
  3. Aral K, Kuwabara Y, Okinaga S. The effect of adrenocorticotropic hormone and dexamethasone, administered to the fetus in utero, upon maternal and fetal estrogens. Am J Obstet Gynecol 1972;113:31622.
  4. Potert AJ. Pregnancy and adrenalcortical hormones. Br Med J 1962;2:96772.

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