Desmopressin in Pregnancy and Breastfeeding

Risk Factor: BM
Class: Hormones / Pituitary agents

Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
References
Questions and Answers

Fetal Risk Summary

Desmopressin is a synthetic polypeptide structurally related to vasopressin. See Vasopressin. Reproduction studies with desmopressin in rats and rabbits at doses up to approximately 0.1 times and 38 times, respectively, the maximum systemic human exposure based on body surface area, did not reveal fetal harm (1).

Breast Feeding Summary

See Vasopressin.

References

  1. Product information. DDAVP. Rhone-Poulenc Rorer Pharmaceuticals, 2000.

Index
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Questions and Answers

desmopressin?, the doctor gave this medaction to my daughter for bed wetting is it safe for her she 5 years old i know it lowers your sodium in kids please help if anyone knows about this medaction.i dont want to hurt my daughter please thank you

I learned about this stuff in one of my child psychology classes. It is extremely effective - you do have to watch her sodium levels, but it is very safe and works well. It replaces the natural hormone that tells her when she has to go to the bathroom, and it does not build up in the body at all.

Of course, it only works as long as she is taking it - it is not a cure. As soon as she stops, she will start wetting again.

There are other treatments that work too - wetness alarms that go in her jammies seem to work very well. Limiting fluids at night and getting her up to pee before you go to sleep help too, but I am sure you have tried all that already. It doesn't always work.

The thing is, some kids are just wetters and they will stay dry when their bodies are ready. I and all my cousins, aunts and uncles peed the bed till we were 11 or 12 years old. It may be hormonal or physiological, who knows? Eventually she will outgrow it, but in the meantime, be as casual about it as you can. Get her to help change the bed, buy GoodNites pull ups, and be sympathetic. She hates peeing the bed already, the worst thing you can do is let anyone make her feel any more ashamed than she already is.

Good luck!

My lab has diabetes insipidus, what are the side effects of Desmopressin?, He is only 6/12 and was diagnosed w/ diabetes insipidus last Ocotober and has been on Desmopressin the synthetic hormone in an eye drop form since Oct. He went from an active dog to a lifeless stuffed animal, he doesn't want to do anything he used to do. He is also on thyroid meds. He was just at the vet last month and all of his levels are normal. Does anyone know the side effects of desmopressin b.c. I think that is causing all of his terrible side effects. I just want my old dog back :(

This is something I found when researching DI...

Therapy is not mandatory for DI as long as the pet has unlimited access to water, and is kept in an environment where constant urination is not a problem. This usually applies to outdoor pets. Therapy with DDAVP can be administered intermittently, when severe thirst and excess urination is especially undesirable, for example, if guests are visiting. Unrestricted access to water is absolutely imperative.

Follow-up

Optimal treatment for a pet with diabetes insipidus requires both home and professional care, with follow up being critical. Administer prescribed medications and alert your veterinarian if you are experiencing problems treating your pet. Follow up includes:


Periodic rechecks by your veterinarian, especially if the diabetes insipidus is suspected to be caused by a tumor affecting the part of the brain responsible for making ADH.


Seek immediate veterinary care if any illness develops that causes vomiting or causes the pet to reduce his water intake, as there is a risk of life-threatening dehydration if water is withdrawn from pets with DI for even a few hours.


Does your dog have unlimited access to plenty of fresh water? Did the vet do plenty of tests to rule out other illnesses which can also have the same symptoms of DI?

The diagnostic tests recommended will help differentiate DI from these other conditions that can cause excessive thirst and urination:


Diabetes mellitus (excessive sugar in the blood)

Renal glycosuria (excessive sugar in the urine, but not diabetic)

Chronic kidney failure

Pyometra (infection of the uterus)

Hypercalcemia, a condition of excessively high calcium levels in the blood

Liver failure

Hyperadrenocorticism, also called Cushing's disease, a condition of overactive adrenal glands

Pyelonephritis, an infection of the kidneys

Hypokalemia (low potassium levels in the blood)

Hypoadrenocorticism, also called Addison's disease, a condition of underactive adrenal glands

Hyperthyroidism (excessive thyroid activity)

Acromegaly (excessive production of growth hormone)

Psychogenic polydipsia (excessive drinking due to psychological reasons, such as a change in the pet's environment


I'd definitely talk to the vet about other forms of treatment, such as:

Treatment In-depth

Desmopressin acetate (also called DDAVP) is a synthetic form of the hormone ADH. It is the standard therapy for central DI. It comes in two forms: injection and nasal drops. The nasal spray can be transferred to a sterile eye dropper bottle and applied to the eye if the dog won't tolerate nasal drops. One to four drops administered once or twice a day usually controls the clinical signs. (which you are currently using)

Chlorpropamide may reduce urine output in some dogs, although results can be inconsistent. Severe forms of central DI often don't respond.

Thiazide diuretics – while it may seem paradoxical to give a dog with DI a diuretic to increase urine output, the net result is usually a reduction in overall urine output.

Salt restriction has a net effect of reducing urine output, and may be used sometimes as the sole therapy for central DI.

Good luck.

What's the difference between vasopressin and desmopressin?,

Desmopressin is chemically related to a natural hormone, vasopressin, which is produced in the body by the pituitary gland It is used to supplement vasopressin which is produced in insufficient quantities by patients with diabetes insipidus. Desmopressin mimics the action of vasopressin on the kidneys which results in concentration of the urine and hence normal urine volume and flow. Desmopressin is relatively specific in its action on the kidney so that it has little or no vasopressin-like activity elsewhere in the body. This medicine can also be delivered into the nostril (and therefore close to the pituitary gland) from where it is well absorbed into the circulation. When taken in tablet form, a relatively large amount of Desmopressin is destroyed in the stomach and before it is absorbed into the circulation. For this reason, you will note that there is a substantial difference in dosage between Desmopressin tablets and the intranasal forms

WOW a great answer. Don't you think?

As a doctor how to prescripe MINIRIN (desmopressin acetate) nasal spray for treatment of nocturnal enuresis ?, What is the initial dose to begin with ,what is the mentainance dose ,how long should it be administered and how to stop the treatment ,would it be be sudden or gradual withdrawal ,and if gradual ,how?

This link below should help some:

http://www.merck.com/mmpe/lexicomp/desmo...

also try the drugs@fda website

If Desmopressin and Vasopression are viable treatments for Alzheimer's, why aren't they used in the USA?, It is effectively used off-label in the USA, with very positive results.

Drugs must be approved by the FDA in order to be sold within the United States. It could be that we have a similar drug sold under another name, or that there is not enough research at this time, or the company has not attempted to export the drug to the United States.

Also, it may seem relatively inexpensive in Europe, but you must remember that many Europeans have a universal healthcare system which subsidizes much of their medical/drug costs. You may have seen a price that may not reflect true market value.

Hope this helps!

What happens when you drink alcohol while on desmopressin for diabetes insipidous? ?,

Your best bet for something that specific is to speak to a professional in the health care industry. Just give your local pharmacy a call, and speak to the pharmacist on staff and be specific. Don't try and skirt the issue with them, be totally honest and they'll be more than happy to answer your questions. Here is SOME information for you...

Cheers and best wishes

Did my k-9, who has insipidus diabetes and is now taking desmopressin, have a seizure?, Appproximately 20 - 30 minutes after receiving her third dosage (in the eye), she had what appeared to be a seizure. Her back hunched over, her body became very rigid while yet trembling, and she was unable to stand unassisted. Episode lasted about 15 - 20 minutes. Does this sound like a seizure? Were the meds and/or the number of dosages perhaps the problem?

We had a cat who got insulin shots and he appeared to have seizures when he was low. He would fall on his side and drooled. We would give him cake mate. My mom was a vet assistant for 20 years and she saw this a lot. Good going with the timing when you call the vet explain all the details. He may have more than diabetes going on. Good luck.

Desmopressin is not effective in treatment of nephrogenic DI. Why?.?, Desmopressin is not effective in treatment of nephrogenic DI. Why?.

Wow,interesting question!

The answer is that the kidney is "resistant" to desmopressin.Therefore the kidney doesn't respond to desmopressin and urine output is increased.There have been identified some genetic causes of nephrogenic DI and also some acquired ones(such as side-effect to lithium and amfotericin-B,or polycystic renal disease).

Desmopressin is only active in Central(or cranial) diabetes insipidus.Central DI is caused by damage to the hypothalamus because of a stroke,tumour,head injury and rarely in pregnancy(Sheehan syndrome).In central DI antidiuretic hormone(ADH) is not produced.
Therefore desmopressin is used(instead of the human ADH) and kidney responds by concentrating the urine and decreasing the urine output.

desmopressin simple question.... =]?, Okay, so I have a medication called "desmopressin" to help me quit wetting the bed....but it says to refrigerate it...why?

What would happen if I didn't?

......I need to know these answers!

Thanks in advance :)

Technically desmopressin tablets does not have to be refrigerated. It's recommended storage temp is 68-77 degreeds F or room temp. By refridgerating, you prevent it from ever reaching above the extreme temperature. The reason why you have to keep it in a cool place is because the drug is a protein consisting of proteins. These protiens are sensitive to heat just like in our body. Put it this way, egg has lots of protein, if you heat it, it turns to a completely different form. Not to mention this drug mimics the vasopressin hormone or Anti diuretic hormone in your body. If not stored correctly, the drug will lost its efficacy and not show the results that it was intended for.

Question about desmopressin (DDAVP) and alcohol?, If you have to pee a lot when you drink beer, would taking DDAVP help?
Also, is it dangerous?

No I don't think it would help. You may get water intoxification.


There are no restrictions on food, beverages, or activities while you are taking desmopressin unless your doctor directs otherwise