Indapamide in Pregnancy and Breastfeeding

Risk Factor: BM*
Class: Diuretics

Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
References
Questions and Answers

Fetal Risk Summary

Indapamide is an oral active antihypertensive-diuretic of the indoline class that is closely related to the thiazide diuretics (see also Chlorothiazide for a discussion of this class of diuretics). No evidence of impaired fertility, fetal harm, or effect on postnatal development was observed in mice, rats, or rabbits given doses up to 6,250 times the therapeutic human dose during pregnancy (1). However, fetal growth retardation has been reported in rats dosed at 1000 mg/kg/day (2).

In an FDA surveillance study of Michigan Medicaid recipients involving 229,101 completed pregnancies conducted between 19851992, 46 newborns had been exposed to indapamide during the 1st trimester (F. Rosa, personal communication, FDA, 1993). Three (6.5%) major birth defects were observed (two expected). Details on the malformations were not available, but no anomalies were observed in six defect categories (cardiovascular defects, oral clefts, spina bifida, polydactyly, limb reduction defects, and hypospadias) for which specific data were available.

In general, diuretics are not recommended for the treatment of pregnancy-induced hypertension because of the maternal hypovolemia characteristic of this disease.

[*Risk Factor D if used in pregnancy-induced hypertension.]

Breast Feeding Summary

No reports describing the use of indapamide during lactation have been located. The closely related thiazide diuretics have been used to suppress lactation (see Chlorothiazide).

References

  1. Product information. Indapamide Tablets, USP. Mylan Pharmaceuticals, 2000.
  2. Seki T, Fujitani M, Osumi S, Yamamoto T, Eguchi K, Inoue N, Sakka N, Suzuki MR. Reproductive studies of indapamide. Yakuri to Chiryo 1982;10:132535, 133753, 13551414. As cited in Shepard TH. Catalog of Teratogenic Agents. 6th ed. Baltimore, MD:Johns Hopkins University Press, 1989:347.

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Questions and Answers

is there a class action lawsuit against the drug indapamide?, there are known incidences of the drug inducing a prolonged QT heartbeat and ventricular fribrulation.

I could find no verification of that.

My dad has been taking Indapamide for cholestorol treatment and has got pains in his sides? Anyone got ideas?, For those of you familiar with the drug and have taken it, do you recognise the side effect mentioned above? Thanks

Indapamide is used to treat high blood pressure and NOT chloestorol. It works like a diuretic ( fluid tablet ) and cause imbalances of elctrolytes in the body. This imbalance can leed to cramping ( mainly due to magnesium deficiency ). But if the pain persist, you should tell him to go back to the doctor.

If your dad is taking a cholestrol tablet such as a 'statin', then muscle pain is more common and is likely. So double check again as indapamide is an anti-hypertensive and is not used for cholestrol.

indapamide may increase the bilirubin in the blood test?, medicine

yes, has to do with the livers ability to process it, keeps it circulating. doesn't lyse extra RBCs.

Indapamide tablet depletes Potassium from body.Why doctors prescribe for reducing Cholesterol?why not ban it?, Symptoms of Potassium depletion ,Weakness,dizziness,lethargy ( for details see Wikipedia ).I suffered all.After stopping Indapamide I feel better.Now I have to make up for lost Potassium eating banana,Orange,potato,cooked tomato in addition to leafy vegetables.

That helped a lot. One must weigh the lesser evil. I will take indapamide if it will cure me, then take additional kalium also for my hypopotassemia.