Mannitol in Pregnancy and Breastfeeding

Risk Factor: C
Class: Diuretics

Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
References
Questions and Answers

Fetal Risk Summary

Mannitol is an osmotic diuretic. No reports of its use in pregnancy following IV administration have been located. Mannitol, given by intra-amniotic injection, has been used for the induction of abortion (1).

Breast Feeding Summary

No data are available.

References

  1. Craft IL, Mus BD. Hypertonic solutions to induce abortions. Br Med J 1971;2:49.

Index
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Questions and Answers

Can Staphylococcus aureus isolated on the Mannitol Salts Agar? How did you come to this conclusion?, Can Staphylococcus aureus isolated on the Mannitol Salts Agar? How did you come to this conclusion?

If s, aureas can metabolize mannitol.

If an injectabel contains 20%of mannitol, how many mls of the injection should be administered to provide?, 100 gm of mannitol?

20% is 20gm / 100ml

setup

(20gm) / (100ml) = (100gm) / (xml)

solve for x

((100ml) * (100gm)) / 20gm = x

500ml = x

If you have any questions or problems, email me.

If an IV solution contains 2% mannitol, how many milliliters of the solution should be administered to provide?, a patient with 30 grams of mannitol? Does anyone have any idea how to do this? I need help!

First, let's assume (since the question doesn't say) that it is a 2% (weight/volume) solution. This means there are 2 grams of mannitol for every 100 mL of solution.

So, now we just need to use dimensional analysis to get our answer.

30 g mannitol x (100mL solution/2 g mannitol) = 1500 mL of solution

A quick note:
These types of problems are solved easily if you write down everything you know, what conversion factors you have (like the 2%) and what you need to know. Then just set it up so the right units cancel out. Hope that makes sense, if not contact me and I'll try to explain better.

The IV dose of mannitol is 1.5g/kg, administered as a 15% solution. How many mls of the solution should be adm, The IV dose of mannitol is 1.5g/kg, administered as a 15% solution. How many mls of the solution should be administered to a 150 pound patient?

It's allowable to round to 70 kgs = 154 lbs.

We'l use that.

70 x 1.5g = 105 grams

You want 105 grams in solution.

700 ml x 0.15g/ml = 105 grams

Can Streptococcus epidermis be positive or negative in MSA or mannitol fermentation result?,
we did this practical.we say its negative.

but the thing is, one of the other groups got same results but when it was marked, the teacher put a big cross..

I believe that you are referring to Staphylococcus epidermidis, not Streptococcus......

Staph epidermidis does NOT ferment mannitol. It WILL grow on the media, but not ferment the sugar.

Staphylococcus spp. are highly salt tolerant and will grow in a hyperosmotic environment, but Staph. epidermidis will not ferment the sugar mannitol.

I'm including a website from the Univ. of South Carolina Medical School as a source...see below.

The indicator in the media is phenol red. If the mannitol is fermented, the pH drops and the color of the indicator changes to a bright yellow as the acid levels increase.

What is mannitol salt test for and whats a positive test result?,

Please see the link below for a full description. Basically it's a test for the presence of Staphylococcus. Since Staphylococcus is salt tolerant, it can grow in a medium where other organisms do poorly.

How would pseudomonas aeruginosa appear on a Mannitol Salt Agar plate?,

If it is negative it will appear pink.
You need to google this, just ask the question exactly as you did on here, it should take you to pour plates and what they look like.
Then if you are being tested by looking at pour plates and slides in the lab you will know what you are looking at. Also find out why they do not do this test in blood agar. Read up on selective and non selective tests also..

If an intravenous solution contains 2 percent mannitol?, How many milliliters of the solution should be administered to provide a patient with 30 grams of mannitol?

Density of water = 1 gram per cm3
2% is 2 g per 100g of water or solution (unspecified in the question). However, it doesn't matter at all for the accuracy required. Let us assume that in each 100 g of solution there are 2 g of Mannitol, and that the density of the solution is 1 g per litre. Accurate enough for this dilute solution.
We need 15 times more solution therefore we need 100X15 g of water = 1,500g of water giving 1.5 litres of water and 1.5 litres of solution to the accuracy required.

what is the mechanism of converting fructose into sorbitol and mannitol ?, as said in the title i need to find that mechanism so any help would be great

thanks

It is simply reduction. You have to reduce the carbonyl group and you will get mannitol and sorbitol (which only have alcohol group, and cannot be reduced further). When reducing fructose, a hydrogen gets added to the carbonyl carbon and depending on which side it attaches to you will get either mannitol or sorbitol. The ratio should actually be 1:1 for both reduced sugars.

Mannitol is absorbed by the gastrointestinal tract and has renal clearance properties similar to inulin. Expla, Mannitol is absorbed by the gastrointestinal tract and has renal clearance properties similar to inulin. Explain why a suitable oral dose of mannitol acts as a diuretic?

I think it osmotically pulls water through membranes. It crosses the blood brain barrier where some others cannot. This is why it also is used to decrease pressure in the cranium.