Acyclovir is not working

 Category: Acyclovir

Questions and Answers

How fast does Acyclovir work on cold sores?

My doctor prescribed Acyclovir for what she thought might be a cold sore (which I have never had) on the corner of my mouth. I saw her and started taking the medication when the spot was at its worst about 2 days ago. Within the past 48 hours, it has almost completely healed. Does Acyclovir really work this fast?

Yes it does. Once you start taking the medication, things should begin healing within a day or so. Though, I've been told that Acyclovir doesn't work as well on Type I (oral) as it does on Type II (Genital).

Acyclovir is not working for me, i am currently on my 4th day of taking it.?

I have been taking acyclovir(Zovirax the liquid form)for about 4 days now, and the doctor told me to take it for 5 days, and it has shown no signs of it working, i still have my cold sore, i have it on the corner of my mouth, and it constantly keeps on scabbing, then falls off, then scab again then fall off,i had my cold sore for a few months now. Help?

Acyclovir really only shortens the healing time by 0. to 1 day verses taking nothing at all. Sores can last up to 3 weeks so if it lasts much longer you may need to have the doctor re-evaluate the situation

How does acyclovir work?

Please give me a detailed biological response. We know Penicillin and its derivatives attack the cell wall's peptidoglycan and stop the trans-peptidation reaction, and that tetracycline and all the other "-in" attack the ribosomal subunits and stop bacterial protein synthesis, but how does acyclovir (cyclovir, etc.) stop viruses?

Acyclovir is given usually for treatment of herpes virus infection. Acyclovir is actually acycloguanosine. When it enters an infected cell, it is converted to acyclovir monophosphate by the virus encoded thymidine kinase, ie the viral DNA produces the thymidine kinase. Then cellular kinases furthur convert this inot Acyclovir di and triphosphates.

The triphosphate acts as a competitie inhibitor for viral DNA replication because when the DNA polymerase replicates the viral DNA, the acyclovir triphosphates get inserted into the chain as well. This prevents the DNA polymerase from going forward, ie, it gets inhibitited.

Therefore, viral DNA synthesis is reduced, and viral replication is reduced. Acyclovir should be give as soon as possible so that the infection can be controlled.

Does Acyclovir control the herpes virus?

I have oral herpes. I take Acyclovir 800mg 3x a day as needed. I'm wondering if it hill suppress the virus so I don't have outbreaks? Thanks

How does Acyclovir work? I just started on Tuesday

I have taken Acyclovir for about 3 years now, and it has been very effective! I take one pill at the first sign of a cold sore (the burning tingle), and usually, I only have to take that one! It's quite great! I have a cold sore right now --- my first in 2 years!--- just because I didn't get a prescription refill in time. I highly suggest Acyclovir!

My doctor moved me to Valtrex today actually, which is supposed to be better (although more expensive). I'll have to wait and see how well it works.

I tried Lysine before Acyclovir and it did nothing for me.

How many people know that acyclovir does not always work nor prevents the transmission of Herpes?

Why is it that no one promotes the safer treatment of L lysine for Herpes instead of the dangerous pharmaceuticals?
Is it all about money or is this because people are unaware like doctors?
L lysine is safer and more effective along with promoting a good healthy diet high in antioxidants.

causes cancer and birth defects in unborn children L Lysine does not.

I use L-lysine when I get a mouth cold sore I began getting them when I began smoking. They go away really fast and since I quit smoking I do not get them as often except under stress.
Do any of you read the itty bitty information they write as warnings on these pharmaceuticals?


Acyclovir has its place, and so does L-lysine.

An Italian study published in the New England Journal of Medicine in 2004 showed that sero-discordant couples (one poz, one neg) on valacyclovir (Valtrex) suppression therapy who used condoms consistently had impressively low rates of infection in the previously negative partner. It was somewhere close to 90+% prevention of infection. Not bad at all. Not perfect, but better than nothing.

So let's not be slagging the meds so quickly. Homeopathy plays a big role in health, but so do pharmaceuticals.

Taking daily acyclovir for genital herpes, does birth control still work?

I started takin daily acyclovir 200mg (script at wal-mart) and I just got back on birth control (ortho try..whatever..) so I know that birth control doesn't work with antibiotics.. so does my birth control going to cooperate with this daily suppressive therapy for genital herpes?

the acyclovir will not decrease the effects of the bc pills

how long does it take acyclovir to work for genital herpes?

i have been in excruciating pain for days now and i cant sit walk or move at all without being in so much pain i cry and or throw up. lease some one help me. the doctor told me it would help it clear up soon but i don't know. i was told i have genital herpes the day after my 19th birthday too...

It can take up to weeks for it to start working. I am often contacted and pressured by Glaxo Smith Kline to prescribe Valtrex (a similar medication to yours). Yet I find that all of these medications:

1 - Are more expensive then other alternatives
2 - Take longer to work
3 - Are less efective then other methods

These are all oral medications that lose effectiveness when going through the digestive system. As an alternative, you can read more about Herpeset here:

What am i limited to while taking acyclovir?

hey guys i am currently prescribed acyclovir and i have to pretty much take it for the rest of y life and i was wondering where i can fin out what limitations to other things i have whil i take this, other things would include stuff like smoking pot or drinking. . also i like to go to the gym and work out and i want to know if i am limited to certain supplements such as Anabolic Pump PowerFULL and Supercissus, also can i take protein shakes and what not

Looking at the medical sheet for it, you should be ok to take just about anything. Although stomach problems seem common so try to take a whey powder from goat whey if you have a problem with regular whey. Other than that, there is not enough info on interactions with bodybuilding supplements to give you an answer on interactions.

Read at the link below, you may have to try things with your doctor knowing and keep an eye on blood work.


Which is better acyclovir or Valtrex?

I know Valtrex costs more but does it work better than acyclovir?

The big difference between the three antiviral drugs for herpes (Zovirax - which is acyclovir, Famvir - with is famciclovir, and Valtrex - which is valacycovir) is how often you need to take them every day.

Zovirax was the first antiviral available for herpes, and you needed to take it something like five times per day. It was effective, but the drug didn't stay in your system very long, so you needed to take it often.

Famvir was next, and you needed to take it less often than Zovirax, but still more than once a day.

Valtrex is advertised as "once-daily" Valtrex because they finally got the time-release stuff good enough that you only need to take it once per day.

But its all the same stuff, really. And it all works about the same.

Herpes Simplex 1 - am i spreading it, is acyclovir safe?

I've had cold sores since I was a little girl, and while I've been told that a lot of people have this virus, my case is pretty chronic. Every three weeks or so I get an outbreak, some worse than others. When I was younger a doctor prescribed me Acyclovir and it worked wonderfully, but two years later he wouldn't prescribe it anymore - he said it was killing all my white blood cells! It is the only thing that ever made a difference, including Abreva. I am so ashamed of my cold sores and constantly aware of them. There is a lot of misinformation about them and I don't want people to get the wrong idea about me.
Also, I'm confused about the contagious nature of the virus. I understand I shouldn't be kissing anyone with an outbreak, but can I also spread it to their genitals (I DON'T have genital herpes) when doing stuff? Right before I get an outbreak, is it possible that I would accidentally infect someone? :(

Herpes simplex virus (HSV) is extremely common in humans. It’s estimated that as many as 80-90% of the entire human population experience oral herpes infections by the age of twelve years old. Some who are infected with oral herpes will have an acute episode that may appear as infected gums and lips, causing high fevers, but most oftentimes those who have oral herpes will have few if any symptoms. A substantial portion of the population has recurrent oral herpes infection, showing up as annoying "cold sores" on lips and sides of the mouth. Oral herpes does have a tendency to show up elsewhere on the face thus creating the position for not realizing that the infection actually is “oral herpes.”

Herpes infects the nerve cells of the spinal cord in the pelvic region (as is the case for genital herpes) and of the nerve ganglia in the facial region at the base of the brain (as is the case for oral herpes). Herpes is a DNA-type virus, inserting its DNA directly into the nerve endings of the skin, which then leads along nerve fibers to the nucleus of the nerve cell. Once the viral information is inserted into the cell's nucleus, this blending of viral genetic information with human genetic information is permanent (meaning there is no cure and herpes virus remains in the body forever). The nerve cell then becomes somewhat of a “factory” for making more viral particles which can lead to recurring herpes outbreaks or conditions suitable for active viral shedding.

Herpes is not a "skin infection", but rather an infection of nerve cells, by way of the skin. It is not the "skin" that is infected but rather the nerve cell. When the infection becomes active again in the nucleus of the nerve cell, the viral particles flow back out, down the nerve, and out through little blisters that form in the skin. If the quantity of viral particles coming down the nerve cell isn't enough to form a blister, then a number of viral particles can be excreted through the skin without any symptoms at all.

"Genital herpes" and "oral herpes" refer to the location where the herpes infection is found on the individual, not the type of herpes. Most genital herpes is caused by HSV-2, but can be caused by HSV-1 in as many as 30% of new cases. Oral herpes is most often caused by HSV-1, and rarely if ever by HSV-2. Because these locations are often associated with a particular type of herpes (which seem to "take hold" in those particular locations more easily), medical people, websites and literature often equate the location with the herpes type. You might find that people speak of genitally-located herpes infections as HSV-2 and orally-located herpes as HSV-1. However, either virus can occur in either place, and in fact, potentially anywhere on the body depending on the point where infection takes place.

Someone with an HSV-1 lesion on the mouth can transmit the infection to an intimate partner through oro-genital contact with the genitalia of the other (oral sex), causing a recurrent HSV-1 lesion on the genitalia of the partner. Also, other sites of HSV infection can be produced, such as on a finger (often referred to as "herpetic whitlow") or elsewhere.

NOTE: Genital herpes is not always HSV-2 and oral herpes is not always HSV-1.


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