Mesoridazine in Pregnancy and Breastfeeding
Risk Factor: C
Class: Central nervous system drugs
/ Tranquilizers
Fetal Risk Summary
Mesoridazine is a piperidyl phenothiazine. Phenothiazines readily cross the placenta (1). No specific information on its use in pregnancy has been located. Although occasional reports have attempted to link various phenothiazine compounds with congenital malformations, the bulk of the evidence indicates that these drugs are safe for the mother and fetus (see Chlorpromazine).
Breast Feeding Summary
No reports describing the excretion of mesoridazine into breast milk have been located. The American Academy of Pediatrics classifies mesoridazine as an agent whose effect on the nursing infant is unknown but may be of concern (2).
References
- Moya F, Thorndike V. Passage of drugs across the placenta. Am J Obstet Gynecol 1962;84:177898.
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Committee on Drugs, American Academy of Pediatrics. The transfer of drugs and other chemicals into human milk. Pediatrics 1994;93:13750.
