Orphenadrine in Pregnancy and Breastfeeding
Fetal Risk Summary
Orphenadrine is an anticholinergic agent used in the treatment of painful skeletal muscle conditions. In a study using pregnant rats, large oral doses (15 and 30 mg) produced enlarged bladders containing blood, but no other anomalies, in 8 of 159 fetuses (1). No published reports of its use in pregnancy have been located (see also Atropine).
In a surveillance study of Michigan Medicaid recipients involving 229,101 completed pregnancies conducted between 1985 and 1992, 411 newborns had been exposed to orphenadrine during the 1st trimester (F. Rosa, personal communication, FDA, 1993). A total of 11 (2.7%) major birth defects were observed (16 expected), including (observed/expected) 2/4 cardiovascular defects and 1/1 polydactyly. No anomalies were observed in four other defect categories (oral clefts, spina bifida, limb reduction defects, and hypospadias) for which specific data were available. These data do not support an association between the drug and congenital defects.
Breast Feeding Summary
No data are available (see also Atropine).
Beall JR. A teratogenic study of chlorpromazine, orphenadrine, perphenazine, and LSD-25 in rats. Toxicol Appl Pharmacol 1972;21:2306. As cited in Shepard TH. Catalog of Teratogenic Agents. 6th ed. Baltimore, MD: Johns Hopkins University Press, 1989:4767.
Questions and Answers
Orphenadrine, have you ever had any bad side effects from it?, What were they and how long were you taking these?
(same thing as Norflex)
SIDE EFFECTS: Stomach upset, headache, blurred vision, drowsiness, dizziness, lightheadedness, dry mouth, constipation, difficulty urinating or flushing may occur. If any of these effects continue or become bothersome, inform your doctor. Notify your doctor immediately if you develop: a rapid heart rate, fainting, fever, breathing difficulties, skin rash, mental confusion, depression. To avoid dizziness and lightheadedness when rising from a seated or lying position, get up slowly. Also limit your intake of alcoholic beverages which will aggravate these effects. Use caution performing tasks requiring alertness if this medication causes you to feel drowsy. If you notice other effects not listed above, contact your doctor or pharmacist.
PRECAUTIONS: Tell your doctor if you have: kidney disease, liver disease, bladder problems, heart disease, prostate trouble, ulcers, glaucoma, myasthenia gravis, allergies. This medication should be used during pregnancy only if clearly needed. Discuss the risks and benefits with your doctor. It is not known if this medication appears in breast milk. Consult your doctor before breast-feeding. Limit the use of alcohol while taking this medication since excessive drowsiness or depression can occur.
What would happen if someone take an orphenadrine but broke the pill up like it says not to?, extended 12 hour release formula 100 mg
You'll bust at the seams and blow up.
what is norflex orphenadrine citrate?, what happens if you take more than the recommended dosage? one of my friends decided to take it to get some sort of high and im just wondering if anything will happen.
Well Norflex is a muscle relaxant that also works as a pain killer. It is an opioid that will give the side effects of over dosing or mis dosing a strong pain killer. Like any medication, I would make your friend stop abusing them to get a high becuase there is always a chance of addiction.
Can you take Orphenadrine, with an enlarged prostate?,
Please don't. It can cause urinary retention. You may have to go to the ER for catheterization if your develop retention.
What is Orphenadrine used for?, I work at the same company aas my parents, who are divorced, and I was sitting in my dad's office today and saw a bottle of pills sitting on his desk right next to the keyboard of the computer he was letting me use.
It's called Orphenadrine and I was wondering what it is used for?
Orphenadrine is a drug used to treat pain, muscle spasm and other symptoms of injury and other problems. It is also used for treating some aspects of Parkinson's Disease.
Orphenadrine is used to treat muscle injuries, skeletal muscle tension and rigidity secondary to afflictions such prolapsed discs and degenerative soft tissue disease especially in the lower back, neck, and joints. and other causes of muscle spasms, to potentiate the action of opioid analgesics against moderate to severe neuropathic pain, and it is also used to treat Parkinson's disease.
Orphenadrine is also a component of various preparations for use against headaches of various types especially tension and histamine headaches. It is also helpful in many cases of fibromyalgia.
Let me know if u want to know more about it.....I guess that should help you
can cummadin and orphenadrine citrate 100mg andnaproxen andaciphex rabeprazole sodium cause limp dick?, i have been usig the acid flex drug for three days and now im on mussle relaxer drugs
Those medications should not be causing that, none of them have effects on erection, the coumadin works on blood clotting, the orphenadrine relaxes skeletal muscle(none of that in your penis), naproxen is an antiinflammatory, and aciphex only works in your stomach, so i dont think its related
Orphenadrine and Wellbutrin?, If you take 400mg a day of Wellbutrin, and you took 100mg of Orphenadrine, would there be any negative reaction?
you can check drug interactions online, for eg http://www.medscape.com/druginfo/drugint...
What is a good prescription muscle relaxer?, I am taking Norflex (orphenadrine citrate) 100mg twice a day right now and it is helping a little but I am wondering what would be bit stronger and wouldn't knock me on my @ss. It should be specifically for targeting my neck muscles.
Cyclobenzaprine (Flexeril) works well.