Tetanus/Diphtheria Toxoids (Adult) in Pregnancy and Breastfeeding

Risk Factor: CM
Class: Serums, toxoids, and vaccines / Toxoids

Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
References
Questions and Answers

Fetal Risk Summary

Tetanus/diphtheria toxoids for adult use are the specific toxoids of Clostridium tetani and Corynebacterium diphtheriae adsorbed onto aluminum compounds. Reproduction studies in animals have not been conducted with this product (1).

Tetanus and diphtheria produce severe morbidity and mortality in the mother with mortality rates of 30% and 10%, respectively (2,3). In neonates the tetanus mortality rate is 60%. The risk to the fetus from tetanus/diphtheria toxoids is unknown (2,3). The American College of Obstetricians and Gynecologists Technical Bulletin No. 160 recommends the use of tetanus/diphtheria toxoids in pregnancy for those women at risk who lack the primary series of immunizations or in whom no booster has been given within the past 10 years (2).

Breast Feeding Summary

No data are available.

References

  1. Product information. Tetanus and Diphtheria Toxoids Adsorbed. Lederle Laboratories, 2000.
  2. American College of Obstetricians and Gynecologists. Immunization during pregnancy. Technical Bulletin, Number 160, October 1991.
  3. Amstey MS. Vaccination in pregnancy. Clin Obstet Gynaecol 1983;10:1322.

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