Thyroglobulin in Pregnancy and Breastfeeding

Risk Factor: A
Class: Hormones / Thyroid agents

Contents of this page:
Fetal Risk Summary
Breast Feeding Summary
Questions and Answers

Fetal Risk Summary

See Thyroid.

Breast Feeding Summary

See Thyroid.

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Questions and Answers

I have thyroid cancer, my thyroglobulin continues to be high, should I see a cancer specialist?, I have had 2 ablations, my thyroglobulin is 239, I am concerned and would like to have opinions about seeing a specialist

was it your family doctor who asked for the tests and gave diagnosis?.what is his plan for you?have you not seen a specialist? i don't know what has been done for you thus far,or your last test results or what meds you are on etc. but i would call the doctor today and ask him what's going on.suggest to him you would like to go see a specialist.the doctor you want is called an endocrinologist. ask for the best in town.sometimes we have to take action if the doctor seem to be moving at a snail pace,when we have illness.

Is thyroglobulin stored as colloid within thyroid follicles?,

I do not have enough time to answer your question fully as the answer is complicated, i do however have a web site for you to go to just click on any links that you may need to click on... if you are still having further trouble with this i suggest you ask your teacher to further explain all parts of the thyroid para thyroid and hypothalamus. GOOD LUCK!!

What is a Thyroglobulin AB level test?, And why would my Dr. want to test me for this?

It's a test for thyroid antibodies--which will show if you have a thyroid autoimmune disease. In other words, you'll see if your own immune system is attacking your thyroid, causing it to not work as well as it should. If the test is positive, then you likely have Hashimoto's thyroiditis. Everybody has some antibodies, but to have Hashimoto's you'll have to have a lot.

Your doctor wants the test likely because you are exhibiting some symptoms of thyroid problems.

There are several T3 and T4 hormones in one thyroglobulin molecule?, true or false

True. Proteases in lysosomes are used to digest iodinated thyroglobulin, releasing T3 and T4. Thus, in essence, thyroglobulin is a precursor for the thyroid hormones thyroxine (T4) and triiodothyronine (T3).

what does it mean when your thyroglobulin is elevated?,

It means you have an overactive thyroid and is the primary symptom for diagnosing hyperactive thyroid and Graves' disease.

Is it anything to be concerned about to have a thyroglobulin level of 191.00 on a scale of 2.0-35.0.?, I have Hoshimotos Thyroditis and I think this is nothing of concern. However, I do not want to ignore something if it should be looked into.

Thyroglobulin levels are used to detect and track the progress of thyroid cancers. Among other things like differential diagnosis of Hashimoto's. If you do have Hashimoto's, it is a little more likely that you cancer than most people.
A large increase in the size and number of thyroid cells, as in Hashimoto's, can increase this level. Was the increase in this level rapid?
Do you have any lumps or nodules in or on your thyroid glands?
"Although the thyroid gland enlarges with Hashimoto's' thyroiditis and sometimes even has exaggerated contours called bossilations, Hashimoto's thyroiditis does not form discrete nodules or lumps in the thyroid. If you have Hashimoto's thyroiditis and a thyroid lump, it must be examined completely to insure that this nodule does not represent a cancer. This examination is usually done by needle biopsy to prove whether or not the thyroid lump is benign or malignant. Although you are unlikely to develop thyroid cancer and Hashimoto's thyroiditis together, you are at increased risk for a special type of thyroid cancer called a lymphoma which can be treated and cured if discovered early. Therefore, no thyroid nodule should be ignored."

I assume you are under the care of a physician, hopefully an endocrinologist. Please make an appointment to see him/her as soon as possible. It might be unimportant, but if it is not it is important to act quickly.
~Gary RN

I had a thyroidectomy due to Papillary cancer 7 weeks ago. I just had first blood test, thyroglobulin was .03?, Isn't it supposed to be 0 ?? Does this mean that I have a small portion of my thyroid left to be able to have a level of .03 ??

Did you have R.A.I. treatment? When they do the surgery,there is always a little of your thyroid left behind. With Papillary Cancer, it is common to have a reading like yours for the first year or so. They should check it every 3 months and as long as it is going down, all is well.
One day it should be zero.

I had my surgery and treatment about 1 year ago and mine was .01.

Hope you are doing well. Just remember to keep your blood work up to date so any changes can be noticed.

THYROGLOBULIN Antibodies HIGH ON BLOOD TEST??, Hi I just got back blood tests results and the THYROGLOBULIN Antibodies are 318 which is high, ANA negative, What does this mean? I have been feeling sick, run down last 6 weeks, My arms and legs are VERY achy due to flu from 6 weeks ago. I am scared of these results anyone know what it means

Thyroglobulin antibodies at 318 high indicate you most likely have Hashimoto's Autoimmune Thyroid.

Hashmoto’s is confirmed by two antibodies labs: anti-TPO and TgAb. The first antibody, anti-TPO, attacks an enzyme normally found in your thyroid gland, called the Thyroid Peroxidase, which is important in the production of thyroid hormones. The second antibody, TgAb, attacks the key protein in the thyroid gland, the thyroglobulin, which is essential in the production of the T4 and T3 thyroid hormones. Note: it is unfortunately common for a doctor to only do ONE test, and you need BOTH tests, since you can be normal in one and high in another! We have also noted that saliva does not always accurately detect Hashi’s as well as blood tests do.

WHAT IS HASHIMOTOS? Hashimoto’s Thyroiditis is an autoimmune thyroid disease in which your thyroid is being attacked by your own immune system via antibodies, attempting to destroy your gland as if it’s some vile enemy. The attack causes an inflammation and gradual destruction of your thyroid gland and can go on for years. It may be the most common thyroid disease, especially with women.

WHAT ARE SYMPTOMS OF HASHIMOTOS? For many, the symptoms are silent–the early stages of the autoimmune attack. But eventually, you start to notice the same symptoms of hypothyroid, including poor stamina, easy fatigue, feeling cold, gaining weight, dry hair and skin, constipation, etc. As it progresses, you may feel very hypo one day, and very hyper another, which is caused by the destruction of your thyroid. Additionally, since the cells of your thyroid become inefficient in converting iodine into thyroid hormones, your thyroid compensates by swelling or enlarging, and you can have a feeling of tightness around your throat or a sore throat as a result. The swelling can be called a goiter. You might also see variations in your lab work–high one time, low the next, high the next, etc.

Here is the link I like the best to describe Hashimoto's or any Hypothyroid related conditions:

You were negative for ANA, which is good! This means that you do not have any of the below disorders:

Antinuclear antibodies (ANA), detected by indirect immunofluorescence, aid in the diagnosis of connective tissue disorders including systemic lupus erythematosus (SLE), mixed connective tissue disease, Sjögren’s syndrome
and scleroderma1-5. ANA occur in about 95% of SLE patients as well as patients with other connective tissue diseases. ANA may also occur in other disorders such as chronic active hepatitis and primary biliary cirrhosis6-8

Don't be scared. I have Hashimoto's too & it is controlled by taking a Thyroid supplement daily. Once you begin taking this, in about 3-4 weeks you will start feeling like your old self again. I would also suggest getting the anti-TPO test for a definite confirmation diagnosis. Don't worry, you will be feeling better soon with the right Thyroid dosage.Feel free to email me in the future if you have any questions or need help with info on meds or treatment information. Good luck!

******I have had Hashimoto's Thyroiditis for about 10 years & have controlled my condition easily with meds. I have never had an Thyroid enlargement that was significant. My endocrinologist indicates to me that this can be controlled & I probably won't need surgery ever.

*****************EDIT: Mary56 read this article :

Yes, you can treat the high Thyroglobulin antibodies even though your TSH is OK. It can actually slow down the progression of the disease. As the study states, you still take Thyroid meds & it can help lower the anti-bodies. It really will help you feel better & have better results long-term.Talk with your Dr. about it, if he/she resists show them this article.

High thyroglobulin level?, Recently, I had a thyroid biopsy on my thyroid nodule and was lucky enough to find no cancer cells present. However, my thyroglobulin level is very high, 679 ng/mL compared to the normal range of 2.0 - 35 ng/mL. I know that other conidtions also cause elevated thyroglobulin level. But a level that is almost 20 times higher that normal makes me worry. Could experts on thyroid disease give me some advices? Thank you very much in advance.


I don't know if you know this or not but when your thyroid level is high your thyroid is actually low and when it's low it means it's high. I know it makes no sense but it is true. Your Dr can give you meds to take and you will have to take them everyday for the rest of your life. they will help raise or lower your thyroid. Your thyroid controls everything in your body. From hair growth, body heat, moods. It is as important to a body as estrogen is. Please check with your Dr about it.

WHat do this THYROGLOBULIN blood test please??, Hi I just got back blood tests results and the THYROGLOBULIN Antibodies are 318 which is high, ANA negative, What does this mean? I have been feeling sick, run down last 6 weeks, My arms and legs are VERY achy due to flu from 6 weeks ago. I am scared of these results anyone know what it means

Thyroglobulin Blood Test is a blood test used to measure the amount of Thyroglobulin (abbreviated Tg); a protein that stores thyroid hormone in your blood.
This test usually done on a thyroid cancer patient.
Blood sample was drawn from a vein in the patient's arm for the test. It is used to monitor the radioactive treatment progress of the thyroid cancer.
This test is done in regular intervals after a patient completed the thyroid cancer treatment to monitor for cancer recurrence.

I am not sure if you have thyroid cancer but a high count of Thyroglobulin Antibodies could mean certain abnormal thyroid growth which would make you feel tired most of the time. You may be able to fell it when you touch your neck.

ANA (Antinuclear Antibody Test) helps screen for autoimmune disorders and is most often used as one of the tests to diagnose systemic lupus. ANA negative usually is
a good condition.

You should speak to your physician to discuss and find out more details.
Anyhow, don't worry too much; radioactive treatment and hormone replacement will be able to solve the problem.

I wish you healthy and well.
God bless..

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