Vaccine, Escherichia Coli in Pregnancy and Breastfeeding
Fetal Risk Summary
Escherichia coli (E. coli) vaccine is a nonpathogenic strain of bacteria used experimentally as a vaccine. Two reports of its use (strains O111 and 083) in pregnant women in labor or waiting for the onset of labor have been located (1,2). The vaccines were given to these patients in an attempt to produce antimicrobial activity in their colostrum. No adverse effects in the newborn were noted.
Breast Feeding Summary
Escherichia coli (E. coli strains O111 and 083) vaccines were given to mothers in labor or waiting for the onset of labor (1,2). Antibodies against E. coli were found in the colostrum of 7 of 47 (strain 0111) and 3 of 3 (strain 083) treated mothers but in only 1 of 101 controls. No adverse effects were noted in the nursing infants.
- Dluholucky S, Siragy P, Dolezel P, Svac J, Bolgac A. Antimicrobial activity of colostrum after administering killed Escherichia coli O111 vaccine orally to expectant mothers. Arch Dis Child 1980;55:55860.
Goldblum RM, Ahlstedt S, Carlsson B, Hanson LA, Jodal U, Lidin-Janson G, Sohl-Akerlund A. Antibody-forming cells in human colostrum after oral immunisation. Nature 1975;257:7979.